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Rationally designed regimens that integrate targeted inhibitors, epigenetic modulators, metabolic drugs and immunotherapies are being tested in preclinical models and clinical trials

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In practice, many protocols do not treat this as an either/or decision at all, and instead combine the two mechanisms a point covered in the next section

These healthspan improvement findings have profound implications for longevity research, development of geroprotective therapies, and understanding how senescent cell accumulation contributes to the functional decline characteristic of biological aging

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